A Theoretical Study of the Relationships between Electronic Structure and CB1 and CB2 Cannabinoid Receptor Binding Affinity in a Group of 1-Aryl-5-(1-H-pyrrol-1-yl)-1-H-pyrazole-3-carboxamides

Table 3

Beta coefficients and t-test for significance of coefficients in (10).

	Beta	𝑡 (24)	𝑃 level
𝑆^𝑁8 (LUMO + 2)*	−0.75	−9.10	<0.0000001
𝑆^𝐸19 (HOMO − 1)*	0.34	3.49	<0.002
𝑆^𝑁1 (LUMO + 2)*	0.33	3.70	<0.001
𝐹20 (HOMO − 2)*	−0.33	−3.75	<0.001
𝐹16 (HOMO − 2)*	−0.22	−2.77	<0.01