Review Article
Histopathological Variants of Cutaneous Squamous Cell Carcinoma: A Review
Table 1
Histological differences between low-grade and high-grade SCC.
| | Low-Grade SCC | | Well to moderately differentiated: intercellular bridges and keratin pearls | | Tumor cells arranged in solid or sheet-like patterns | | Association with solar damage and precursor actinic keratosis | | Diameter less than 2 cm | | Depth less than 2 mm |
| | High-Grade SCC | | Poorly differentiated: clear-cell, sarcomatoid, or single cell features | | Presence of infiltrating individual tumor cells | | Arising de novo or in site of prior injury (ulcer, burn scar, or osteomyleitis) | | Perineural and/or perivascular invasion | | Diameter greater than 2 cm | | Depth greater than 2 mm |
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