Basal Cell Carcinomas in Gorlin Syndrome: A Review of 202 Patients

Table 1

Diagnostic criteria for Gorlin Syndrome. A diagnosis can be made when 2 major or 1 major and 2 minor criteria are fulfilled.

Major criteria	Minor criteria
Lamellar (sheet-like) calcification of the falx or clear evidence of calcification in an individual younger than age of 20 years	Childhood medulloblastoma
Jaw keratocyst	Lympho-mesenteric or pleural cysts
2 or more palmar/plantar pits	Macrocephaly (OFC >97th centile)
Multiple BCCs (more than five in a lifetime) or a BCC before age of 30 years.	Cleft lip/palate
First degree relative with Gorlin Syndrome	Vertebral/rib anomalies such as bifid/splayed/extra ribs or bifid vertebrae
	Preaxial or postaxial polydactyly
	Ovarian/cardiac fibromas
	Ocular anomalies (cataract, developmental defects, and pigmentary changes of the retinal epithelium)