The Contribution of Electron Paramagnetic Resonance to Melanoma Research

Figure 3

(a, b) Melanoma B16 metastases in the lungs of mice: picture of freeze-dried lungs with metastases (a) and the respective 2D transversal EPR image (b). (c, d) 2D EPR image through a section of thickness 500 mm of a paraffin-embedded human melanoma (d) and the histological section (5 mm thick) from a contiguous slice (c). Scale bars: 1 mm. (e, f) In vivo studies on B16 melanoma in mice. Melanoma grown in subcutaneous tissue (e) and in vivo EPR image obtained using a low-frequency EPR spectrometer with a head-coil loop-gap resonator. Scale bar: 2 mm. Pictures coming from Vanea et al. [15].