Pigmented Nodular Basal Cell Carcinomas in Differential Diagnosis with Nodular Melanomas: Confocal Microscopy as a Reliable Tool for In Vivo Histologic Diagnosis
Figure 2
(a) Dermoscopic image of pigmented nodule exhibiting a bluish veil on the entire lesion and numerous vessels with corkscrew aspect (original magnification 20). (b) RCM image ( mm) imaged at upper dermis level, showing the cauliflower aspect with numerous plump bright cells overlying all lesion area (scale bar: 500 m). (c) RCM image ( mm) showing reflective aggregates of tightly packed cells with peripheral palisading (white arrow) surrounded by dark clefts. Inside the tumoral nest bright filaments and dots were present (yellow arrowhead) (scale bar: 50 m). (d) Histology showing basaloid tumoral nests enclosed by connective tissue stroma. Melanin was present inside the tumoral nests and also in the surrounding stroma where numerous melanophages were detected (H&E section; original magnification 100).
