Deciphering Squamous Cell Carcinoma Using Multidimensional Genomic Approaches

Figure 4

Whole-genome tiling-path array profile of an oral low-grade dysplasia. Normalized log2 signal intensity ratios were plotted using SIGMA software [85, 86]. Cytoband pattern corresponding to the data points was drawn to the left of each data plot. The red and green vertical lines represent signal intensity ratios from −1 to +1 with an increment of 0.5. The magnified insets (for regions of chromosome 4, 8, and 9) include segmental copy number gain highlighted in orange and copy number loss highlighted green.