Deciphering Squamous Cell Carcinoma Using Multidimensional Genomic Approaches

Table 1

Genome-wide methods for identifying genetic alterations.

Alteration	Method of genome-wide analysis	References
Chromosomal translocation	Spectral karyotyping (SKY)	[8–12]
DNA copy number	Array comparative genomic hybridization (aCGH)	[13–17]
	Digital karyotyping and genome sequencing
Loss of heterozygosity	Single-nucleotide polymorphisms (SNPs) analysis	[18, 19]
Mutation	Gene-specific, exomic, and whole-genome sequencing	[20–23]