Characterization of Ex Vivo Expanded Tumor Infiltrating Lymphocytes from Patients with Malignant Melanoma for Clinical Application

Figure 2

Phenotypes. FACS determination of phenotypes of TIL cultures pre- (open circles) and post-REP (closed circles) are represented from six patients. The overall T-cell effector memory like phenotype (CD3⁺CD45R0⁺CCR-7 ^Lo ) is preserved after REP with a sustained low expression of CD57 and intermediate CD25 expression. CD28 remains unchanged, while CD62L and CD27 is downregulated, indicating a differentiation towards a later effector stage.

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