Molecular Network Associated with MITF in Skin Melanoma Development and Progression

Figure 1

MITF-centered schematic scheme of cellular signaling on melanoma development and progression. Open arrows indicate direct transcriptional targets of MITF. The amount of transcripts of these targets is regulated by direct MITF binding to cis-elements in their promoter sequence. Black arrows or lines indicate signal cascades associated with melanoma development and progression. Arrows or lines toward MITF mean direct association by binding to the MITF promoter region or MITF protein. αMSH: melanocyte-stimulating hormone; BCL2: B-cell leukemia/lymphoma 2; BRN2: brain-2; CDK2/CDK4: cyclin-dependent kinase 2/4; CREB: cAMP-responsive element-binding protein; DCT: dopachrome tautomerase; DIA1: diaphanous homolog 1; FZD: frizzled; GSK3β: glycogen synthase kinase 3 beta; HGF: hepatocyte growth factor; HIF1α: hypoxia inducible factor 1, alpha subunit; MC1R: melanocortin 1 receptor; MDM2: transformed mouse 3T3 cell double minute 2; PMEL17: premelanosome protein; RB1: retinoblastoma 1; SCF: stem cell factor; SNAI2: snail homolog 2; SOX10: Sry-related HMG box 10; TYR: tyrosinase, WNT: wingless-related MMTV integration site.