Germ Cell Proteins in Melanoma: Prognosis, Diagnosis, Treatment, and Theories on Expression

Table 2

Cancer testis gene and associated melanoma prognostic marker.

CTA	Thickness	Ulceration	Metastasis	RFS	Reference
NY-ESO1	√		√	−	[21, 24, 25]
MAGE-A1	√	√		−	[21]
MAGE-A4				−	[21]
XAGE-1			√		[27]
MAGE-A3			√	+*	[23, 37]
MAGE-C1/C2			√		[29]

√: the gene is associated with thicker tumors, ulcerated tumors, and metastatic tumors.
(−) A decrease in time of relapse free survival.
(+) increase in time of relapse free survival.
∗Only found in stage III melanoma.