Diagnostic Role of Chromosomal Instability in Melanoma

Table 2

The sensitivity and specificity of recent studies using FISH assays to identify melanoma.

Probe set used	Research study	Sensitivity %	Specificity %	Melanoma tested; (+/total)	Typical nevi tested; (+/total)	Ambiguous lesion tested	Number of experts reviewing results
chromosome 6, 7, 11, and 20	Hossain et al. [30]	94%	94%	29/31	2/32	0	2
6p25 (RREB1); 6q23 (MYB); CEP6; 11q13 (CCND1)	Gerami et al. [6]	86.7	95.4	72/83	4/86	12/27	2
	Fang et al. [31]	82	98	41/50	1/50*	0	**
	Vergier et al. [32]	85	90	17/20	2/19	23/90	3
	Abásoloet al. [33]	100	94.1	27/27	1/9	1/9	2
	Gaiser et al. [34]	50***	60***	7	3	12	3
9p21 (CDKN2A)
6p25 (RREB1); 11q13 (CCND1)	Gerami et al. [35]	94	98	**/51	**/51	0	**
8q24 (MYC)
D18Z1
DXZ1	Satoh et al. [36]	100	100	8/8	0/8	0	**
DYZ3

*Corrected for tetraploidy.
**Exact number not specified.
***Based on clinical behavior.