Review Article
Potential Role of Meiosis Proteins in Melanoma Chromosomal Instability
Table 3
The Potential ramifications of the aberrant expression of different meiotic proteins.
| Meiotic Pathway | Potential ramification in mitosis | Potential Meiotic Proteins involved |
| DS DNA strand breaks | Insertions, deletions, translocations | SPO11 | Error prone polymerase | Point mutations | POLB | Failure of cohesin ring digestion | Tetraplody, polyploidy | REC8/SGO2 | Unresolved chismata | Anaphase bridging | REC8 | Failure of kinetochore separation | Chromosomal missegregation | REC8/SGO2 | Misalignment of kinetochores | Chromosomal missegregation | REC8/monopolins |
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