Review Article

Potential Role of Meiosis Proteins in Melanoma Chromosomal Instability

Table 3

The Potential ramifications of the aberrant expression of different meiotic proteins.

Meiotic PathwayPotential ramification in mitosisPotential Meiotic Proteins involved

DS DNA strand breaksInsertions, deletions, translocationsSPO11
Error prone polymerasePoint mutationsPOLB
Failure of cohesin ring digestionTetraplody, polyploidyREC8/SGO2
Unresolved chismataAnaphase bridgingREC8
Failure of kinetochore separationChromosomal
missegregation
REC8/SGO2
Misalignment of kinetochoresChromosomal
missegregation
REC8/monopolins