Simulators of Squamous Cell Carcinoma of the Skin: Diagnostic Challenges on Small Biopsies and Clinicopathological Correlation

Figure 20

Bowen disease: medium-power magnification showing skin with full thickness epidermal dysplasia which is characterized by loss of the nuclear polarity, nuclear pleomorphism, and mitoses at all levels. The undulating deep epidermal contour and presence of eccrine ducts that have been colonized by the tumor cells (arrow) can potentially mimic invasion. (H&E, ×200).