Characterization of the Merkel Cell Carcinoma miRNome

Table 2

MCC-miR candidates identified via NGS. Lists of top fifteen microRNAs upregulated and downregulated in MCC (𝑛=3) versus other tissues (1 melanoma, 1 SCC, 1 BCC, and 1 normal skin sample) and list of fifteen microRNAs expressed in MS-1, based on NGS data.

Upregulated in MCC; versus other skin cancers^1		Upregulated in MCC; versus normal skin^1		Downregulated in MCC; versus all other samples^1		Highly expressed in MS-1
microRNA	Fold change^2	microRNA	Fold change^2	microRNA	Fold change^2	microRNA	RPKM
miR-885	234.3	miR-183	54.6	miR-455	−100.0	miR-182	441,774
miR-1252	159.4	miR-182	44.3	miR-146a	−33.3	miR-183	406,019
miR-190b	72.3	miR-96	26.4	miR-125b-2	−16.7	miR-10b	368,383
miR-876	69.7	miR-7-2	9.0	miR-224	−16.7	miR-30d	354,071
miR-873	62.2	miR-7-1	8.4	miR-125b-1	−16.7	let-7i	302,976
miR-1468	42.5	miR-769	6.0	miR-452	−12.5	miR-30a	256,918
miR-3065	33.8	miR-708	5.8	miR-27a	−8.3	miR-21	231,060
miR-3074	19.9	miR-93	5.7	miR-503	−6.7	miR-26a	230,375
miR-1250	15.6	miR-106b	5.7	miR-34a	−5.3	miR-9-2	152,761
miR-502	15.2	miR-9-2	4.7	miR-378d-2	−4.8	miR-20a	118,839
miR-660	14.4	miR-532	4.7	miR-24-2	−4.0	miR-532	109,596
miR-501	9.3	miR-9-3	4.7	miR-193a	−4.0	miR-93	108,909
miR-708	9.2	miR-9-1	4.7	miR-378i	−3.6	miR-340	89,562
miR-532	8.2	miR-340	4.0	miR-22	−3.0	miR-7-1	73,329
miR-500a	7.6	miR-192	3.5	miR-34c	−2.9	miR-96a	60,009

1Inclusion criteria: >100 reads in all MCC samples; ²Fold change (default cut-off ≥ ±2.0) between mapped counts observed between individual groups.