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Mouse Models of the Skin: Models to Define Mechanisms of Skin Carcinogenesis

Call for Papers

Skin cancer (basal cell, squamous cell carcinoma, and melanoma) is the most common human cancer, and the multistage model of mouse skin carcinogenesis has been on the forefront for providing clues regarding the cellular, biochemical, and genetic events linked to the initiation, promotion, and progression steps of skin cancer formation. Mouse models of the skin have provided us with unique tools to elucidate the mechanisms of skin carcinogenesis such as identification of both oncogenes and tumor suppressors, the biology of tumor-host cell relationships as well as the role of inflammation in skin cancer. Due to the organized and predictable nature of skin development, mouse models are useful to define the role of stem cells in the development of normal tissues as well as cancer. In the era of molecular targeting and advanced chemotherapeutics, mouse models of the skin provide preclinical models to test and validate new drug combinations as well as elucidating new drug targets to fight cancer.

We invite authors to submit original research and review articles that highlight the use of mouse models of the skin that investigate the multistep nature of skin carcinogenesis, define stem cell biology, skin development, and uses for investigating molecular targeting in cancer. Potential topics include, but are not limited to:

  • Mouse models for multistep carcinogenesis
  • Transgenic and gene knockout mice as models for skin cancer
  • Genetics of skin carcinogenesis
  • Origin of epidermal cancer
  • Modeling human skin cancer in vivo
  • Hair follicle stem cells and skin cancer
  • Modeling melanoma initiation and progression in mouse
  • Modeling human skin cancer in vivo
  • Photocarcinogenesis
  • Cytokines and skin cancer
  • Tumor-host interactions
  • Inflammation and skin cancer

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/jsc/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/jsc/mmsmdm/ according to the following timetable:

Manuscript DueFriday, 4 January 2013
First Round of ReviewsFriday, 29 March 2013
Publication DateFriday, 24 May 2013

Lead Guest Editor

  • Deric L. Wheeler, Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, 3159 Wisconsin Institutes for Medical Research, 1111 Highland Avenue, Madison, WI 53705, USA

Guest Editors

  • Ajit K. Verma, Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, 7103 Wisconsin Institutes for Medical Research, 1111 Highland Avenue, Madison, WI 53705, USA
  • Mitchell Denning, Department of Pathology, Stritch School of Medicine, Loyola University Chicago, Chicago, IL, USA