Can Biofluids Metabolic Profiling Help to Improve Healthcare during Pregnancy?

Table 2

Summary of the impact of disorders on the metabolite profiling of 2nd trimester amniotic fluid, urine, and blood plasma.

Disorder	FM	Prediagnostic GDM	Pre-PTD	Pre-PROM	Chromosomal disorders
Biofluid
Amniotic fluid	+++	++	+	+	+
Maternal blood plasma	+++*	+	^a	^b	+**
Maternal urine	+++	++	+	^b	++**

^aInsufficient sample numbers at this stage, ^bno metabolite changes noted, *different malformation types, and **chromosomal disorders are apparently distinguishable, + small impact, ++ medium impact, +++ large impact.