The V30M Amyloidogenic Mutation Decreases the Rate of Refolding Kinetics of the Tetrameric Protein Transthyretin

Table 1

Apparent refolding kinetic constants of WT- and V30M-TTR at a protein concentration of 1 μM in the absence of denaturant, obtained by extrapolation of the refolding rates at different urea concentrations, using the equation: ln𝑘=ln𝑘⁰+𝑚[𝑢𝑟𝑒𝑎].

	𝑘^01(M^−1s^−1)	𝑘^02(M^−1s^−1)
WT-TTR	2.2 × 10^6	8.1 × 10^3
V30M-TTR	1.8 × 10^3	1.9 × 10^2