Synthesis, Spectral Characterization, and In Vitro Cytotoxicity of N-2′-Hydroxyethyl-Substituted Azacholestanes Prepared from 6-Oxocholestanes by Modified Schmidt Reaction

Table 1

Yields of the reaction between protonic acid and lewis acids with 2-azidoethanol starting from ketone 1, 2 or 3.

Compounds	H2SO4; (% yield)	BF3–OEt2; (% yield)	TiCl4; (% yield)	SnCl4; (% yield)
4	75	50	45	20
5	70	45	40	12
6	65	45	40	—