Synthesis, Spectral Characterization, and In Vitro Cytotoxicity of N-2′-Hydroxyethyl-Substituted Azacholestanes Prepared from 6-Oxocholestanes by Modified Schmidt Reaction

Table 2

Cytotoxicity of compounds 4–6 against the cell lines.

Compounds	Cytotoxicity of Cell lines (μM)
	HCT116	HepG2	HFL1
4	4.66	5.02	Not active
5	2.76	3.12	Not active
6	4.51	5.18	Not active
Doxorubicin	2.53	2.88	Not active

The highest concentration tested was 25 μM for compounds 4–6 and all the values are an average of three observations.