Utilization of a Green Brominating Agent for the Spectrophotometric Determination of Pipazethate HCl in Pure Form and Pharmaceutical Preparations

Table 5

Robustness and ruggedness of the proposed methods.

Parameters	A	B	C	D	E
	2.0 𝜇g mL^−1	4.0 𝜇g mL^−1	6.0 𝜇g mL^−1	3.0 𝜇g mL^−1	3.0 𝜇g mL^−1
	Recovery (%) ± RSD%^a
Robustness
No variation^b	99.90±0.45	100.10±0.50	99.95±0.34	99.70±0.65	99.80±0.73
Oxidant (100𝜇gmL^−1BrO3^−)
0.8 mL	99.86±0.81	99.50±0.64	99.75±0.76
1.2 mL	99.92±0.53	100.04±0.53	99.90±0.94
Oxidation time
2.0 min	99.95±0.72	100.20±1.06	99.45±0.47
10 min	100.05±0.91	99.70±0.80	100.30±0.57
1,10-Phenanthroline (0.2%)
0.8 mL				99.85±0.74
1.2 mL				100.10±0.98
Ammonia (1 : 1)
0.8 mL				99.72±0.56
1.2 mL				100.25±0.78
FAS (5 × 10^−3 mol L^−1)
1.3 mL					99.78±0.85
1.7 mL					99.55±0.97
SCN^− (1.0 mol L^−1)
1.8 mL					100.40±0.96
2.2 mL					99.65±0.48
Ruggedness
Interanalysis’	99.40±1.14	100.04±1.07	99.85±0.95	99.70±0.88	99.65±0.79
Interinstruments’	100.13±1.46	99.90±1.39	100.05±1.27	99.75±1.32	99.95±1.19

aAverage of three determinations.
^bFollowing the general assay procedure conditions.