Simultaneous Quantification of Paracetamol and Caffeine in Powder Blends for Tableting by NIR-Chemometry

Table 4

Validation results of NIR method for paracetamol and caffeine assays in powder blends.

Concentration level (paracetamol)	Mean paracetamol; content (mg/tablet)	Trueness		Precision		Accuracy
		Relative; bias (%)	Recovery; (%)	Repeatability; (RSD %)	Intermediate precision; (RSD %)	Relative; tolerance; limits (%)	Tolerance limits (mg/tablet)
Paracetamol
43.55	43.90	0.805	100.8	0.384	0.393	[−0.11, 1.72]	[43.50, 44.30]
48.39	48.44	0.101	100.1	0.188	0.185	[−0.32, 0.52]	[48.64, 48.64]
53.23	53.07	−0.307	99.69	0.187	0.163	[−0.68, 0.06]	[53.26, 53.26]
Caffeine
4.355	4.437	1.880	101.88	1.34	3.19	[−6.26, 9.92]	[4.08, 4.82]
4.839	4.808	−0.659	99.34	2.49	2.79	[−7.53, 6.21]	[4.48, 5.14]
5.323	5.137	−1.592	98.41	1.83	1.63	[−5.28, 2.01]	[4.95, 5.33]