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Journal of Signal Transduction
Volume 2010 (2010), Article ID 268589, 10 pages
http://dx.doi.org/10.1155/2010/268589
Review Article

GIMAP Proteins in T-Lymphocytes

1Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Tykistökatu 6 B, P.O. BOX 123, 20520 Turku, Finland
2Department of Pharmacology, Drug Development and Therapeutics, Drug Discovery Graduate School, University of Turku, Itäinen Pitkäkatu 4 B, 20520 Turku, Finland

Received 28 January 2010; Accepted 16 June 2010

Academic Editor: Karl Matter

Copyright © 2010 Sanna Filén and Riitta Lahesmaa. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

(GIMAPs) GTPase of the immunity associated protein family are a novel protein family of putative small GTPases. GIMAPs are mainly expressed in the cells of the immune system and have been associated with immunological functions, such as thymocyte development, apoptosis of peripheral lymphocytes and T helper cell differentiation. GIMAPs have also been linked to immunological diseases, such as T cell lymphopenia, leukemia and autoimmune diseases. In this review we examine the role of GIMAP proteins in T-lymphocyte biology.