GIMAP Proteins in T-Lymphocytes

Figure 2

Thymocyte development. T-cells are developed in the thymus. The development can be defined by cell surface expression of CD4 and CD8. During the process, the thymosytes mature from ${\text{CD}4}^{-}$${\text{CD}8}^{-}$ double negative (DN) cells into CD4⁺CD8⁺ double positive (DP) cells and finally into single positive (SP) CD4⁺ or CD8⁺ cells. The DN cells can be further categorized into DN1, DN2, DN3 and DN4 cells. ISP: immature single positive.