Posttranslational Processing and Modification of Cathepsins and Cystatins

Table 4

Contribution of cathepsin L or B on bone resorption.

Inhibitors (10^-6M)		Cathepsin L	Cathepsin B	Bone resorption
Control		100	100	100	%
Pepstatin	−	103	104	104	%
CA-074	−	100	2.2	94	%
E-64	+	10	2	40	%
Cystatin α	+	3.1	4.3	18	%
Chymostatin	+	9.8	101	6	%
CA-148	+	0	100	0	%