Effect of PAR-2 Deficiency in Mice on KC Expression after Intratracheal LPS Administration

Figure 1

Chemokine and cytokine expression in BALF and lung homogenates after intratracheal LPS instillation. 10 μg of LPS (E. coli O111:B4) was instilled into the left lungs of wild-type (PAR2^+/+, white bars) and PAR-2^−/− (black bars) mice for indicated time periods. BALF and lungs were collected, and lungs were homogenized. ELISAs on BALF were performed for KC (a), MIP-2 (b), and TNF-α (c). ELISAs on lung homogenates were performed for KC (d), MIP-2 (e), and TNF-α (f). 𝑛≥4. *𝑃<0.05; **𝑃<0.001 by two way ANOVA posttest.

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