563128.fig.002a
(a)
563128.fig.002b
(b)
563128.fig.002c
(c)
Figure 2: Podocyte injury induced by mutant α-actinin-4. (a) Potential actions of α-actinin-4 K256E and other FSGS-associated mutants. (b, c) Potential mechanisms for the cytoskeletal (b) and proteotoxic (c) effects of mutant α-actinin-4 in the podocyte.