Schematic of the structural domain of human Src (Upper) and v-Src (Lower). The Src molecule is composed of an N-terminal myristoylation sequence (Myr) attached to the SH4 domain, a unique region followed by SH3 and SH2 domains, a linker region (L), a kinase domain (SH1 domain) that contains Tyr419, and a C-terminal regulatory domain (R) that contains Tyr530. v-Src protein differs from Src in a number of ways, with one major difference being the lack of a regulatory domain (R) at the C-terminal sequence.
