NPM-ALK: The Prototypic Member of a Family of Oncogenic Fusion Tyrosine Kinases

Table 2

Known or suspected dimerization/oligomerization domains in ALK fusion partners. Dimerization/oligomerization domains present ALK fusion partners that are postulated to mediate dimerization/oligomerization are indicated. With the exception of the basic domain of EML4-ALK, these domains have not been experimentally proven to mediate dimerization/oligomerization of the respective fusion proteins. The basic domain of EML4 also possesses a coiled-coil motif which is postulated to mediate dimerization.

Dimerization/oligomerization domain	Fusion protein	Reference
Coiled-coil	TPM3-ALK	[23, 25]
	TPM4-ALK	[25]
	TFG-ALK	[27]
	KIF5B-ALK	[54]
	PPFIBP1-ALK	[55]
	MYH9-ALK^*	[45]
Leucine zipper	RANBP2-ALK	[44]
Basic domain/coiled-coil	EML4-ALK	[49]
PB1 domain	SQSTM1-ALK	[51]
WD40 repeats	SEC31L1-ALK	[46]
Triskelion assembly motifs	CLTC-ALK	[33]

^* The MYH9 coiled-coil domain is truncated in the fusion protein and may not be functional.