Review Article

MAP Kinases and Prostate Cancer

Figure 1

Mitogen-activated protein kinase (MAPK) signaling. MAP kinases are activated by upstream kinases such as MAP kinase kinase (MAPKK), that include MEKs 1, 2, 3, 4, 5, 6, and 7. In turn, MAPKKs are activated by several different MAP kinase kinase kinases (MAPKKKs). Numerous stimulatory factors such as cytokines, mitogens, or death receptors can activate MAPKKKs. Each MAPK, depending on the stimulus and cell type, can phosphorylate different transcription factors.
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