Estrogen Regulates MAPK-Related Genes through Genomic and Nongenomic Interactions between IGF-I Receptor Tyrosine Kinase and Estrogen Receptor-Alpha Signaling Pathways in Human Uterine Leiomyoma Cells
Figure 4
Increased colocalization of phosphorylated (p)MAPKp44/42 and pERser118 in UtLM cells exposed to -estradiol . Localization of pERser118 expression (red), pMAPKp44/42 (green) and colocalization of both (yellow) in UtLM cells following E2 treatment. The staining was primarily localized to the nucleus. Inset: Negative control with normal mouse and rabbit IgG. Representative of three independent experiments.
