|
Heat map
| Symbol | Accession
| Description | siScr
| silGF-IR
|
| position | number | +E2/−E2 | +E2/−E2 |
|
| A01 | ARAF | NM_001654 | V-raf murine sarcoma viral oncogene homolog, transduction of mitogenic signal to nucleus | 23.3 | −1.2 |
| A07 | CCNB2 | NM_004701 | Cyclin B2, related to transforming growth factor beta-mediated cell cycle control | 94.0 | 1.3 |
| A08 | CCND1 | NM_053056 | Cyclin Dl, cell cycle regulation, Gl-S transition | 2.4 | −3.7 |
| A09 | CCND2 | NM_001759 | Cyclin D2, cell cycle regulation, Gl-S transition | 1.4 | 29.7 |
| A10 | CCND3 | NM_001760 | Cyclin D3, cell cycle regulation, Gl-S transition | 2.3 | 1652.0 |
| B02 | CDK4 | NM_000075 | Cyclin-dependent kinase 4, A subunit of protein kinases complex in cell cycle G1 phase | 2148.2 | 2.5 |
| B06 | CDKN1C | NM_000076 | Cyclin-dependent kinase inhibitor 1C (p57, Kip2) | 37.6 | 1.3 |
| B08 | CDKN2B | NM_004936 | Cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) | 198.8 | 1.1 |
| B12 | COL1A1 | NM_000088 | Collagen, type I, alpha 1 | 7.3 | −15.8 |
| C03 | DLK1 | NM_003836 | Delta-like 1 homolog (Drosophila), contains EGF-like repeat, related to fibrosis | −2.5 | 604.7 |
| C04 | E2F1 | NM_005225 | E2F transcription factor 1 | 3.1 | −1.9 |
| C05 | EGFR | NM_005228 | Epidermal growth factor receptor | 1.5 | 67.2 |
| C06 | EGR1 | NM_001964 | Early growth response 1, a zinc finger protein, and nuclear transcriptional regulator | 55.5 | 166.6 |
| C07 | ELK1 | NM_005229 | Transcription factor, a nuclear target of ras-raf-MAPK signaling cascade | 4.4 | 1.3 |
| C09 | ETS2 | NM_005239 | V-Ets erythroblastosis virus E26 oncogene homolog 2 (avian), a transcriptional factor | −1.4 | >5000 |
| C10 | FOS | NM_005252 | Leucine-zip-protein, dimerizes with Jun, involved in AP-1 complex | 32.8 | 1.1 |
| C11 | GRB2 | NM_002086 | Growth factor receptor-bound protein 2 | 12.4 | −3.0 |
| D01 | HSPA5 | NM_005347 | Heat shock 70 kDa protein 5 (glucose-regulated protein, 78 kDa), related to protein transport in cells | −4.0 | >5000 |
| D03 | JUN | NM_002228 | Jun oncogene, interacts with target DNA sequence to regulate gene expression | 14.7 | −1.7 |
| D05 | KSR1 | NM_014238 | A scaffold protein connecting MEK to RAF | 12.1 | −1.3 |
| D06 | MAP2K1 | NM_002755 | Mitogen-activated protein kinase kinase 1 | 470.9 | −2.7 |
| D08 | MAP2K2 | NM_030662 | A MAP kinase kinase, activates MAPK1/ ERK2 cascade | 84.2 | −6.2 |
| D10 | MAP2K4 | NM_003010 | A MAP kinase kinase, activates MAPK8/JUK cascade | 411.0 | 3.0 |
| D11 | MAP2K5 | NM_002757 | A MAP kinase kinase, activates MAPK7/ERK5 cascade | 253.7 | −1.1 |
| E02 | MAP3K1 | NM_005921 | A MAP kinase kinase, activates ERK/JUK cascade | 1.5 | 53.1 |
| E05 | MAP3K4 | NM_005922 | A MAP kinase kinase, activates JUK/MAPK cascade | 475.8 | 1951.0 |
| E06 | MAP4K1 | NM_007181 | A MAP kinase kinase, acts upstream of JUN-N terminal pathway | 1.0 | >5000 |
| E07 | MAPK1 | NM_002745 | Mitogen-activated protein kinase, encoding of MAPKp42, activates Elk-1 | 1101.7 | 1.3 |
| E09 | MAPK11 | NM_002751 | A MAP kinase kinase related to p38 | 111.1 | 2.4 |
| E11 | MAPK13 | NM_002754 | A MAP kinase kinase related to p38 | 107.8 | 3.2 |
| F01 | MAPK3 | NM_002746 | Mitogen-activated protein kinase 3, encoding of MAPKp44, activates Elk-1 | 19.9 | 1.6 |
| F03 | MAPK7 | NM_002749 | Mitogen-activated protein kinase 7, encoding of ERK4/5 | −495.9 | 1.3 |
| F09 | MAX | NM_002382 | MYC-associated factor X, a transcription factor | 3.0 | 28.1 |
| G02 | MYC | NM_002467 | V-myc myelocytomatosis viral oncogene homolog (avian), a transcription factor | 11.4 | 51.3 |
| G07 | RAC1 | NM_006908 | Ras-related C3 botulinum toxin substratel (Rho family), GTPase of Ras family of small GTP-binding proteins | 4552.5 | 3.1 |
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