Research Article

The Concept of Divergent Targeting through the Activation and Inhibition of Receptors as a Novel Chemotherapeutic Strategy: Signaling Responses to Strong DNA-Reactive Combinatorial Mimicries

Figure 4

Representative histograms illustrating Iressa, mechlorethamine (HN2), Iressa + HN2, ZRBA4, and ZR2003-induced cell cycle arrest in U87MG (a), U87/EGFR (b), and U87/EGFRvIII (c) glioma cells following a 48 h treatment. Cell cycle perturbations following concomitant treatment with 1 μM octreotide (OCT) are shown in the lower panels. *Shows statistical differences, within the same phase of the cell cycle, between drug alone and drug + OCT ( 𝑃 < 0 . 0 5 ).
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