The Concept of Divergent Targeting through the Activation and Inhibition of Receptors as a Novel Chemotherapeutic Strategy: Signaling Responses to Strong DNA-Reactive Combinatorial Mimicries
Figure 7
Relative growth inhibition of ZRBA4, ZR2003, and equimolar combination of Iressa + mechlorethamine (HN2) in U87MG (a), U87/EGFR (b), and U87/EGFRvIII (c) isogenic glioma cells. Cells were exposed to each drug for 6 days, and growth inhibition was measured by alamar blue assay (see Materials and Methods for details). Each point represents three independent experiments run in triplicate.
