The Concept of Divergent Targeting through the Activation and Inhibition of Receptors as a Novel Chemotherapeutic Strategy: Signaling Responses to Strong DNA-Reactive Combinatorial Mimicries
Figure 8
Representative Annexin V/propidium iodide (PI) intensity dot blots of U87MG (a) and U87/EGFR (b) cells treated for 24 (upper panels) or 48 h (lower panels) with Iressa, mechlorethamine (HN2), Iressa + HN2, ZRBA4, or ZR2003. Cell death was determined by Annexin V and propidium iodide (PI) staining (see Materials and Methods for details). Data are the mean of two independent experiments run in duplicate.