Research Article

The Concept of Divergent Targeting through the Activation and Inhibition of Receptors as a Novel Chemotherapeutic Strategy: Signaling Responses to Strong DNA-Reactive Combinatorial Mimicries

Figure 9

Assessment of apoptotic effects induced by Iressa ± mechlorethamine (HN2), ZRBA4, and ZR2003. U87MG (a) and U87/EGFR (b) cells were treated for 24 (i) or 48 h (ii). Levels of cell death were determined by Annexin V and propidium iodide (PI) staining. Bars for apoptotic cell death represent the mean percentage of Annexin-V-positive cells. Total cell death encompasses early and late apoptotic as well as necrotic cell death. Data are the mean of two independent experiments run in duplicate. *Statistically different from control ( 𝑃 < 0 . 0 5 ).
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