The Concept of Divergent Targeting through the Activation and Inhibition of Receptors as a Novel Chemotherapeutic Strategy: Signaling Responses to Strong DNA-Reactive Combinatorial Mimicries
Table 2
Inhibition of U87MG, U87/EGFR, and U87/EGFRvIII cell growth by Iressa ± mechlorethamine (HN2), ZRBA4, and ZR2003, alone or in combination with 1 μM octreotide (OCT), as assessed by the alamar blue assay.
U87
U87/EGFR
U87/EGFRvIII
(μM)
(μM)
(μM)
OCT
n/a
n/a
n/a
Iressa
Iressa + OCT
HN2
HN2 + OCT
n/a
Iressa + HN2
Iressa + HN2 + OCT
n/a
ZRBA4
ZRBA4 + OCT
ZR2003
ZR2003 + OCT
Values are presented as mean ± SEM and are representative of 3 experiments run in triplicate.