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Journal of Signal Transduction
Volume 2012 (2012), Article ID 358476, 13 pages
http://dx.doi.org/10.1155/2012/358476
Review Article

The Role of Phosphoinositide 3-Kinase Signaling in Intestinal Inflammation

1Mucosal Immunology Laboratory, Department of Pediatrics, 114 16th Street, Massachusetts General Hospital for Children, Charlestown MA 02129, USA
2Neurochemistry Laboratory, Department of Psychiatry, 149 13th Street, Massachusetts General Hospital, Charlestown MA 02129, USA

Received 23 July 2011; Accepted 29 November 2011

Academic Editor: Axel Kallies

Copyright © 2012 Catherine M. Cahill et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The phosphatidylinositol 3-kinase signaling pathway plays a central role in regulating the host inflammatory response. The net effect can either be pro- or anti-inflammatory depending on the system and cellular context studied. This paper focuses on phosphatidylinositol 3-kinase signaling in innate and adaptive immune cells of the intestinal mucosa. The role of phosphatidylinositol 3-kinase signaling in mouse models of inflammatory bowel disease is also discussed. With the development of new isoform specific inhibitors, we are beginning to understand the specific role of this complex pathway, in particular the role of the γ isoform in intestinal inflammation. Continued research on this complex pathway will enhance our understanding of its role and provide rationale for the design of new approaches to intervention in chronic inflammatory conditions such as inflammatory bowel disease.