Functional Mechanisms and Roles of Adaptor Proteins in Abl-Regulated Cytoskeletal Actin Dynamics

Figure 2

Signaling upstream and downstream of Abl leading to actin dynamics. Abl kinase activity, localization, and substrate phosphorylation which are responsible for F-actin dynamics may be modulated by ligand molecules, accessory proteins, phosphorylation by other kinases, and/or adaptor proteins as described in the text. However, the role of adaptor proteins is mainly highlighted in this paper. ECM: extracellular matrix.