Functional Mechanisms and Roles of Adaptor Proteins in Abl-Regulated Cytoskeletal Actin Dynamics
Figure 3
Domain structure of the Abi and Crk family proteins. (a) Modular domains of the Abi and Crk family proteins in mice are illustrated. For the Abi family, WAB (light green): WAVE-binding domain, SNARE (grey): Syntax-1 binding domain which is an overlapping domain of WAB, HHR (red): Hox homology region, SR: serine/threonine-rich region, PP (cyan): polyproline structure, SH3 (orange): SH3 domain [55, 71–75]. For the Crk family, SH2 (blue-green): SH2 domain, SH3 (orange): SH3 (N) and SH (C) domains [56, 57, 76]. Amino acid residues in each protein are numbered; only isoform 1 for Abi2 and Abi3 is shown. (b) Proteins reported to interact with Abi1 and CrkII involved in the regulation of Abl-mediated actin dynamics are shown.
