Review Article
Diverse Roles of JNK and MKK Pathways in the Brain
Table 2
Comparison of phenotypes of Mkk4 flox/flox Nestin-Cre and Mkk7 flox/flox Nestin-Cre mice.
| Phenotype | Mkk4flox/flox Nestin-Cre [37] | Mkk7flox/flox Nestin-Cre [38] |
| Neuronal JNK activity | Suppressed | Suppressed | Age of lethality | Around 3 weeks old | At birth | Brain ventricle size at E18.5 | Not reported | Enlarged | Striatum | Not reported | Reduced | Axon tracts (E18.5) | Unaffected | Greatly reduced | Axon tracts (postnatal) | Less fasciculated | Not determined | Intermediate filaments | Not reported | Accumulate in axons | Autophagic vacuoles | Not reported | Accumulate | JNK phosphorylation in axons | Not reported | Suppressed | L1-positive axons (E18.5) | Unaffected | Reduced | TAG-1-positive axons (E18.5) | Not reported | Reduced | Apoptosis | Unaffected | Unaffected | Cortical layer markers | Not reported | Expressed | Radial migration | Delayed | Delayed | Phosphorylation of c-Jun | Suppressed | Suppressed | Phosphorylation of NF-H | Suppressed | Suppressed | Phosphorylation of MAP1B | Suppressed | Suppressed | Phosphorylation of DCX | Unaffected | Suppressed |
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