ROS-Mediated Signalling in Bacteria: Zinc-Containing Cys-X-X-Cys Redox Centres and Iron-Based Oxidative Stress

Figure 1

Formation of intramolecular disulfide bonds (S–S). Oxidation of a cysteine thiol by H₂O₂ yields a sulfenic acid residue that can undergo reaction with a neighbouring “back door” cysteine thiol to generate a disulfide linkage (S–S). S–S bonds can overtime be returned to the native SH state by reactions with biological thiols (RSH). This picture was adapted from [21].