- About this Journal
- Abstracting and Indexing
- Aims and Scope
- Article Processing Charges
- Articles in Press
- Author Guidelines
- Bibliographic Information
- Citations to this Journal
- Contact Information
- Editorial Board
- Editorial Workflow
- Free eTOC Alerts
- Publication Ethics
- Reviewers Acknowledgment
- Submit a Manuscript
- Subscription Information
- Table of Contents
Journal of Signal Transduction
Volume 2012 (2012), Article ID 704953, 6 pages
The Role of Bacteria in the Pathogenesis of Ulcerative Colitis
Division of Digestive Diseases, Atlanta Veterans Administration Medical Center, Emory University, Whitehead Biomedical Research Building, Suite 201, 615 Michael Street, Atlanta, GA 30322, USA
Received 28 July 2011; Accepted 16 January 2012
Academic Editor: Tadashi Matsuda
Copyright © 2012 Maiko Sasaki and Jan-Michael A. Klapproth. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- E. G. Zoetendal, M. Rajilić-Stojanović, and W. M. De Vos, “High-throughput diversity and functionality analysis of the gastrointestinal tract microbiota,” Gut, vol. 57, no. 11, pp. 1605–1615, 2008.
- G. W. Tannock, “The bowel microbiota and inflammatory bowel diseases,” International Journal of Inflammation, vol. 2010, Article ID 954051, 9 pages, 2010.
- C. L. Sears, “A dynamic partnership: celebrating our gut flora,” Anaerobe, vol. 11, no. 5, pp. 247–251, 2005.
- L. V. Hooper and J. I. Gordon, “Commensal host-bacterial relationships in the gut,” Science, vol. 292, no. 5519, pp. 1115–1118, 2001.
- J. H. Cummings and G. T. Macfarlane, “Collaborative JPEN-Clinical Nutrition Scientific Publications role of intestinal bacteria in nutrient metabolism,” Journal of Parenteral and Enteral Nutrition, vol. 21, no. 6, pp. 357–365, 1997.
- M. Serino, E. Luche, C. Chabo, J. Amar, and R. Burcelin, “Intestinal microflora and metabolic diseases,” Diabetes and Metabolism, vol. 35, no. 4, pp. 262–272, 2009.
- L. L. Presley, J. Ye, X. Li, et al., “Host-microbe relationships in inflammatory bowel disease detected by bacterial and metaproteomic analysis of the mucosal-luminal interface,” Inflammatory Bowel Diseases, vol. 18, no. 3, pp. 409–417, 2012.
- O. Cohavy, D. Bruckner, L. K. Gordon et al., “Colonic bacteria express an ulcerative colitis pANCA-related protein epitope,” Infection and Immunity, vol. 68, no. 3, pp. 1542–1548, 2000.
- L. Prideaux, P. De Cruz, and S. C. Ng, “Serological antibodies in inflammatory bowel disease: a systematic review,” Inflammatory Bowel Diseases. In press.
- D. McGovern and F. Powrie, “The IL23 axis plays a key role in the pathogenesis of IBD,” Gut, vol. 56, no. 10, pp. 1333–1336, 2007.
- M. Sarra, F. Pallone, T. T. MacDonald, and G. Monteleone, “IL-23/IL-17 axis in IBD,” Inflammatory Bowel Diseases, vol. 16, no. 10, pp. 1808–1813, 2010.
- J. C. Barrett, J. C. Lee, C. W. Lees et al., “Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region,” Nature Genetics, vol. 41, no. 12, pp. 1330–1334, 2009.
- M. A. Battle, G. Konopka, F. Parviz et al., “Hepatocyte nuclear factor 4α orchestrates expression of cell adhesion proteins during the epithelial transformation of the developing liver,” Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 22, pp. 8419–8424, 2006.
- K. Schmehl, S. Florian, G. Jacobasch, A. Salomon, and J. Korber, “Deficiency of epithelial basement membrane laminin in ulcerative colitis affected human colonic mucosa,” International Journal of Colorectal Disease, vol. 15, no. 1, pp. 39–48, 2000.
- C. W. Lees, J. C. Barrett, M. Parkes, and J. Satsangi, “New IBD genetics: common pathways with other diseases,” Gut, vol. 60, no. 12, pp. 1739–1753, 2011.
- J. Matricon, N. Barnich, and D. Ardid, “Immunopathogenesis of inflammatory bowel disease,” Self/Nonself. Immune Recognition and Signaling, vol. 1, no. 4, pp. 299–309, 2010.
- U. Gophna, K. Sommerfeld, S. Gophna, W. F. Doolittle, and S. J. O. Veldhuyzen Van Zanten, “Differences between tissue-associated intestinal microfloras of patients with Crohn's disease and ulcerative colitis,” Journal of Clinical Microbiology, vol. 44, no. 11, pp. 4136–4141, 2006.
- L. A. G. Rodríguez, A. Ruigómez, and J. Panés, “Acute gastroenteritis is followed by an increased risk of inflammatory bowel disease,” Gastroenterology, vol. 130, no. 6, pp. 1588–1594, 2006.
- K. O. Gradel, H. L. Nielsen, H. C. Schønheyder, T. Ejlertsen, B. Kristensen, and H. Nielsen, “Increased short- and long-term risk of inflammatory bowel disease after salmonella or campylobacter gastroenteritis,” Gastroenterology, vol. 137, no. 2, pp. 495–501, 2009.
- A. Ternhag, A. Törner, A. Svensson, K. Ekdahl, and J. Giesecke, “Short- and long-term effects of bacterial gastrointestinal infections,” Emerging Infectious Diseases, vol. 14, no. 1, pp. 143–148, 2008.
- T. Jess, J. Simonsen, N. M. Nielsen et al., “Enteric salmonella or campylobacter infections and the risk of inflammatory bowel disease,” Gut, vol. 60, pp. 318–324, 2011.
- C. Schultsz, F. M. Van den Berg, F. W. T. Kate, G. N. J. Tytgat, and J. Dankert, “The intestinal mucus layer from patients with inflammatory bowel disease harbors high numbers of bacteria compared with controls,” Gastroenterology, vol. 117, no. 5, pp. 1089–1097, 1999.
- A. Swidsinski, A. Ladhoff, A. Pernthaler et al., “Mucosal flora in inflammatory bowel disease,” Gastroenterology, vol. 122, no. 1, pp. 44–54, 2002.
- A. Swidsinski, V. Loening-Baucke, and A. Herber, “Mucosal flora in Crohn's disease and ulcerative colitis—an overview,” Journal of Physiology and Pharmacology, vol. 60, supplement 6, pp. 61–71, 2009.
- R. Bibiloni, M. Mangold, K. L. Madsen, R. N. Fedorak, and G. W. Tannock, “The bacteriology of biopsies differs between newly diagnosed, untreated, Crohn's disease and ulcerative colitis patients,” Journal of Medical Microbiology, vol. 55, no. 8, pp. 1141–1149, 2006.
- M. P. Conte, S. Schippa, I. Zamboni et al., “Gut-associated bacterial microbiota in paediatric patients with inflammatory bowel disease,” Gut, vol. 55, no. 12, pp. 1760–1767, 2006.
- S. Sepehri, R. Kotlowski, C. N. Bernstein, and D. O. Krause, “Microbial diversity of inflamed and noninflamed gut biopsy tissues in inflammatory bowel disease,” Inflammatory Bowel Diseases, vol. 13, no. 6, pp. 675–683, 2007.
- S. O. Noor, K. Ridgway, L. Scovell et al., “Ulcerative colitis and irritable bowel patients exhibit distinct abnormalities of the gut microbiota,” BMC Gastroenterology, vol. 10, article 134, 2010.
- D. N. Frank, A. L. S. Amand, R. A. Feldman, E. C. Boedeker, N. Harpaz, and N. R. Pace, “Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases,” Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 34, pp. 13780–13785, 2007.
- J. Galvez, M. E. Rodríguez-Cabezas, and A. Zarzuelo, “Effects of dietary fiber on inflammatory bowel disease,” Molecular Nutrition and Food Research, vol. 49, no. 6, pp. 601–608, 2005.
- F. Lara-Villoslada, O. De Haro, D. Camuesco et al., “Short-chain fructooligosaccharides, in spite of being fermented in the upper part of the large intestine, have anti-inflammatory activity in the TNBS model of colitis,” European Journal of Nutrition, vol. 45, no. 7, pp. 418–425, 2006.
- J. P. Segain, D. Raingeard De La Blétière, A. Bourreille et al., “Butyrate inhibits inflammatory responses through NFκB inhibition: implications for Crohn's disease,” Gut, vol. 47, no. 3, pp. 397–403, 2000.
- B. Kleessen, A. J. Kroesen, H. J. Buhr, and M. Blaut, “Mucosal and invading bacteria in patients with inflammatory bowel disease compared with controls,” Scandinavian Journal of Gastroenterology, vol. 37, no. 9, pp. 1034–1041, 2002.
- P. Lepage, R. Hösler, M. E. Spehlmann et al., “Twin study indicates loss of interaction between microbiota and mucosa of patients with ulcerative colitis,” Gastroenterology, vol. 141, no. 1, pp. 227–236, 2011.
- H. Sokol, B. Pigneur, L. Watterlot et al., “Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients,” Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 43, pp. 16731–16736, 2008.
- N. B. Kumar, T. T. Nostrant, and H. D. Appelman, “The histopathologic spectrum of acute self-limited colitis (acute infectious-type colitis),” American Journal of Surgical Pathology, vol. 6, no. 6, pp. 523–529, 1982.
- I. Mukhopadhya, J. M. Thomson, R. Hansen, S. H. Berry, E. M. El-Omar, and G. L. Hold, “Detection of campylobacter concisus and other campylobacter species in colonic biopsies from adults with ulcerative colitis,” PLoS One, vol. 6, no. 6, article e21490, 2011.
- R. Verma, A. K. Verma, V. Ahuja, and J. Paul, “Real-time analysis of mucosal flora in patients with inflammatory bowel disease in India,” Journal of Clinical Microbiology, vol. 48, no. 11, pp. 4279–4282, 2010.
- L. D. Kalischuk, G. D. Inglis, and A. G. Buret, “Campylobacter jejuni induces transcellular translocation of commensal bacteria via lipid rafts,” Gut Pathogens, vol. 1, p. 2, 2009.
- J. M. Lamb-Rosteski, L. D. Kalischuk, G. D. Inglis, and A. G. Buret, “Epidermal growth factor inhibits Campylobacter jejuni-induced claudin-4 disruption, loss of epithelial barrier function, and Escherichia coli translocation,” Infection and Immunity, vol. 76, no. 8, pp. 3390–3398, 2008.
- R. Kotlowski, C. N. Bernstein, S. Sepehri, and D. O. Krause, “High prevalence of Escherichia coli belonging to the B2+D phylogenetic group in inflammatory bowel disease,” Gut, vol. 56, no. 5, pp. 669–675, 2007.
- S. Schippa, M. P. Conte, O. Borrelli et al., “Dominant genotypes in mucosa-associated Escherichia coli strains from pediatric patients with inflammatory bowel disease,” Inflammatory Bowel Diseases, vol. 15, no. 5, pp. 661–672, 2009.
- S. Sepehri, E. Khafipour, C. N. Bernstein et al., “Characterization of Escherichia coli isolated from gut biopsies of newly diagnosed patients with inflammatory bowel disease,” Inflammatory Bowel Diseases, vol. 17, no. 7, pp. 1451–1463, 2011.
- U. R. M. Bohr, B. Glasbrenner, A. Primus, A. Zagoura, T. Wex, and P. Malfertheiner, “Identification of enterohepatic Helicobacter species in patients suffering from inflammatory bowel disease,” Journal of Clinical Microbiology, vol. 42, no. 6, pp. 2766–2768, 2004.
- J. M. Thomson, R. Hansen, S. H. Berry et al., “Enterohepatic helicobacter in ulcerative colitis: potential pathogenic entities?” PLoS One, vol. 6, no. 2, article e17184, 2011.
- S. Saitoh, S. Noda, Y. Aiba et al., “Bacteroides ovatus as the predominant commensal intestinal microbe causing a systemic antibody response in inflammatory bowel disease,” Clinical and Diagnostic Laboratory Immunology, vol. 9, no. 1, pp. 54–59, 2002.
- M. Minami, T. Ando, A. Okamoto et al., “Seroprevalence of Fusobacterium varium in ulcerative colitis patients in Japan,” FEMS Immunology and Medical Microbiology, vol. 56, no. 1, pp. 67–72, 2009.
- T. Ohkusa, T. Yoshida, N. Sato, S. Watanabe, H. Tajiri, and I. Okayasu, “Commensal bacteria can enter colonic epithelial cells and induce proinflammatory cytokine secretion: a possible pathogenic mechanism of ulcerative colitis,” Journal of Medical Microbiology, vol. 58, no. 5, pp. 535–545, 2009.
- T. Ohkusa, I. Okayasu, T. Ogihara, K. Morita, M. Ogawa, and N. Sato, “Induction of experimental ulcerative colitis by Fusobacterium varium isolated from colonic mucosa of patients with ulcerative colitis,” Gut, vol. 52, no. 1, pp. 79–83, 2003.
- T. Yoshida, T. Sekine, K. I. Aisaki, T. Mikami, J. Kanno, and I. Okayasu, “CITED2 is activated in ulcerative colitis and induces p53-dependent apoptosis in response to butyric acid,” Journal of Gastroenterology, vol. 46, pp. 339–349, 2011.
- T. Ohkusa, K. Kato, S. Terao et al., “Newly developed antibiotic combination therapy for ulcerative colitis: a double-blind placebo-controlled multicenter trial,” American Journal of Gastroenterology, vol. 105, no. 8, pp. 1820–1829, 2010.
- T. Nomura, T. Ohkusa, I. Okayasu et al., “Mucosa-associated bacteria in ulcerative colitis before and after antibiotic combination therapy,” Alimentary Pharmacology and Therapeutics, vol. 21, no. 8, pp. 1017–1027, 2005.
- T. Ohkusa, T. Nomura, T. Terai et al., “Effectiveness of antibiotic combination therapy in patients with active ulcerative colitis: a randomized, controlled pilot trial with long-term follow-up,” Scandinavian Journal of Gastroenterology, vol. 40, no. 11, pp. 1334–1342, 2005.
- N. R. Bullock, J. C. L. Booth, and G. R. Gibson, “Comparative composition of bacteria in the human intestinal microflora during remission and active ulcerative colitis,” Current Issues in Intestinal Microbiology, vol. 5, no. 2, pp. 59–64, 2004.
- K. Fyderek, M. Strus, K. Kowalska-Duplaga et al., “Mucosal bacterial microflora and mucus layer thickness in adolescents with inflammatory bowel disease,” World Journal of Gastroenterology, vol. 15, no. 42, pp. 5287–5294, 2009.