Nucleic Acids in Human Glioma Treatment: Innovative Approaches and Recent Results

Table 1

Advantages and disadvantages of microRNAs, siRNAs, and aptamers.

	miRNAs	siRNAs	Aptamers
Advantages	(i) Chemically synthesized	(i) Chemically synthesized	(i) Chemically synthesized
	(ii) Small size	(ii) Small size	(ii) Small size
	(iii) Sufficiently stable	(iii) Sufficiently stable	(iii) High target selectivity
	(iv) Can be readily chemically modified	(iv) Can be readily chemically modified	(iv) High affinity
	(v) Less immunogenic than proteins	(v) Less immunogenic than proteins	(v) Sufficiently stable
		(vi) Already developed in clinical trials	(vi) Can be readily chemically modified
			(vii) Less immunogenic than proteins
			(viii) Already developed in clinic
Disadvantages	(i) Off-target effects; (ii) Not yet developed in clinical trials	Off-target effects	Only a few aptamers as targeting agents for imaging