Review Article

Nucleic Acids in Human Glioma Treatment: Innovative Approaches and Recent Results

Table 3

Strategies for siRNA delivery across the BBB.

Delivery systemsiRNA targetRef.

Pegylated immunoliposomesEGFR [29]
siRNA/TfR antibody complexes by biotin-streptavidin bridgeLuciferase[65]
Polyethylenimine/siRNA complexesPleiotrophin[66]
Nanoparticles/siRNA complexesHIF-1α[68]
Recombinant adeno-associated virusHec1[69]
Herpes simplex virus 1EGFR; Rad51[70, 71]
Lentiviral vectorsshBcl-2 and S-TRAIL[73]