The Role of Semaphorins and Their Receptors in Gliomas

Table 1

List of semaphorins and their receptors.

Semaphorins	Plexins/Neuropilins	Coreceptors
Class 1
Sema1a	PlexinA	Otk
Sema1b	PlexinA	Otk
Class 2
Sema2a	PlexinB	—
Class 3
Sema3A	Nrp-1; Plexin-A4	L1-CAM
Sema3B	Nrp-1, -2	Nr-CAM
Sema3C	Nrp-1, -2; Plexin-A2, -D1	—
Sema3D	Nrp-1	—
Sema3E	Plexin-D1	—
Sema3F	Nrp-1, -2; Plexin-A1, -A2	Nr-CAM
Sema3G	Nrp-2	—
Class 4
Sema4A	Plexin-B1, -B2, -B3, -D1	Tim-2
Sema4B	Plexin-B1	—
Sema4C	Plexin-B2	—
Sema4D	Plexin-B1, -B2	c-Met; ErbB2; CD72
Sema4E	—	—
Sema4F	—	—
Sema4G	Plexin-B2	—
Class 5
Sema5A	Plexin-B3, -A1, -A3	c-Met; ErbB2; CSPG; HSPG
Sema5B	Plexin-A1, -A3	—
Sema5C	—	—
Class 6
Sema6A	Plexin-A4	—
Sema6B	Plexin-A4	—
Sema6C	Plexin-A1	—
Sema6D	Plexin-A1	VEGFR; NrCAM; Otk
Class 7
Sema7A	Plexin-C1	β1-integrin
Class V
Poxvirus A39R	Plexin-C1	—