The Phosphorylation-Dependent Regulation of Mitochondrial Proteins in Stress Responses

Figure 3

The mechanism of PINK1/Parkin-dependent arrest of mitochondrial motility. Long-range mitochondrial transport relies on the action of the molecular motor complex, which includes KHC, Milton, and Miro. When mitochondria are depolarized, stabilized PINK1 phosphorylates Ser156 of Miro. Subsequent interaction of Parkin with Miro and likely ubiquitination by Parkin causes proteasomal degradation of Miro to arrest mitochondrial motility.