Pathogenic Role of Store-Operated and Receptor-Operated Channels in Pulmonary Arterial Hypertension
Figure 5
channels play a role in membrane depolarization and vasoconstriction. channels remain closed until stimulated to open, after stimulation, channels open causing membrane depolarization and leading to the opening of voltage-dependent channels (VDCC) and contribute to increased levels of causing vasoconstriction. However, when channels open this causes membrane depolarization, which closes VDCC, preventing the influx of , leading to PASMC relaxation, and causing vasodilatation [35].
