Pathogenic Role of Store-Operated and Receptor-Operated Channels in Pulmonary Arterial Hypertension
Figure 7
DAG activates voltage-independent ROC channels on the plasma membrane, resulting in influx into the cell (ROCE). Plasma membrane receptors such as G-protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs) can be activated by various ligands, which then leads to activation of phospholipase C (PLC or ). PLC can then hydrolyze phosphatidylinositol 4,5-bisphosphate into inositol 1,4,5-trisphosphate and diacylglycerol (DAG). DAG remains in the plasma membrane and then activates receptor-operated channels (ROCs) also resulting in influx.
