Journal of Signal Transduction

Review Article

A Network Map of FGF-1/FGFR Signaling System

Table 1

List of genes that are reported to be transcriptionally and translationally regulated by FGF-1 in humans and other mammals.


	Gene symbol	Up-/down regulation	mRNA/Protein	Experiment	Organism	Tissue/cell line/type	PubMed ID	Transcriptional regulator	Regulator Gene ID	PubMed ID

1	APOE	Up	mRNA and protein	RT-PCR, Western blot	Rat	Astrocytes	18216067, 19229075, 17548887, 15627653
2	BAMBI	Down	mRNA and protein	RT-PCR, Western blot	Human	Preadipocytes	22187378
3	CCND1	Up	mRNA and protein	Gene chip array, Western blot	Human, rat	MG63 osteoblastic cells, Rat Wister bladder tumor cells (NBT-II)	15572039, 18189245
4	CDK5R1	Up	mRNA and protein	Q-PCR, Western blot	Rat	PC12 cells	19249349
5	CDKN1A	Up	mRNA and protein	RT-PCR, Western blot	Human, mouse, rat	Chondrocytes, REtsAF cells	16091747, 16153144, 11779141, 10364154	STAT1	6772	11779141, 10364154
6	CEBPA	Up	mRNA and protein	RT-PCR, Western blot	Human, mouse	Preadipocytes, 3T3-L1 cells	17068114
7	CEBPB	Up	mRNA and protein	RT-PCR, Western blot	Human, mouse	Preadipocytes, 3T3-L1 cells	17068114
8	COX2	Up	mRNA and protein	Northern blot, ELISA	Human, rabbit	Cardiac muscle microvessel endothelial cells	8790580, 2107185
9	EGR1	Up	mRNA and protein	Q-PCR, Western blot	Mouse, rat	PC12 cells, Hippocampal neuronal cell line HT22, human periodontal ligament cells	19249349, 20649566, 18179472, 24396070	STAT3, SP1	6774, 6667	24396070
10	FOS	Up	mRNA and protein	RT-PCR, northern blot (mouse and rat), Immunohistochemistry, Western blot	Mouse, rat, human	3T3 cells, Adipocytes, ENU1564 cell, Astrocytes of periventricular zone of third ventricle, SUM-52PE cells	16309174, 2507555, 18041768, 11172932, 20388777
11	JUN	Up	mRNA and protein	RT-PCR, Western blot	Rat	ENU1564 cells	18041768
12	JUNB	Up	mRNA and protein	Gene chip array (Rat), Western blot	Rat, human	Rat Wister bladder tumor cells (NBT-II), SUM-52PE cells	18189245, 20388777
13	MDM2	Up	mRNA and protein	RT-PCR, Western blot	Rat	REtsAF cells	16091747
14	MMP14	Up	mRNA and protein	Northern blot, Gene chip array, Western blot	Human, rat	Prostate cancer cell line, LNCaP, Rat Wister bladder tumor cells (NBT-II)	14673954, 18189245	STAT3	6774	14673954
15	MMP9	Up	mRNA and protein	RT-PCR, Gene chip array, Western blot	Rat	ENU1564 cells, Rat Wister bladder tumor cells (NBT-II)	18041768, 18189245	RELA, JUN, FOS	5970, 3725, 2353	18041768
16	MYC	Up	mRNA and protein	Northern blot (Mouse), Western blot	Mouse, human	3T3 cells, SUM-52PE cells	16309174, 20388777
17	NOS2	Up	mRNA and protein	RT-PCR, Western blot	Rat	Astrocytes	16524372
18	PLAU	Up	mRNA and protein	RT-PCR, ELISA	Human	Fibroblasts	12008951
19	PPARG	Up	mRNA and protein	RT-PCR, Western blot	Human, mouse	Preadipocytes, 3T3-L1 cells	17068114, 22187378
20	SLC2A4	Up	mRNA and protein	RT-PCR, Western blot	Human, mouse	Preadipocytes, 3T3-L1 cells	22187378, 17068114
21	THY1	Up	mRNA and protein	Northern blot, Western blot	Rat	PC12 cell lines	11084019
22	TNFRSF12A	Up	mRNA and protein	RT-PCR, Immunoblot	Rat	Cardiomyocytes	19629561
23	NGF	Up	mRNA and Protein	RT-PCR, Enzyme Immuno assay	Rat	Hippocampal astrocytes, skin fibroblasts, Primary spinal cord astrocyte	1377078, 15773903
24	VEGFA	Up	mRNA and protein	Real time PCR, ELISA	Human	Primary human airway smooth muscle cells	22205500
25	ACPL2	Down	mRNA	Microarray	Mouse	Osteoblast cells	18505824
26	ARG1	Up	mRNA	Gene chip array, Q-PCR	Rat	Rat Wister bladder tumor cells (NBT-II)	18189245
27	ATP2A2	Up	mRNA	RNA gel blot	Mouse	NIH 3T3 cells	7506544
28	AXIN2	Down	mRNA	Microarray	Mouse	Osteoblast cells	18505824
29	BGLAP	Up	mRNA	in situ hybridization	Mouse	Mouse calvaria cells (coronal sutures)	12674336
30	CTSC	Up	mRNA	Gene chip array	Rat	Rat wister bladder tumor cells (NBT-II)	18189245
31	DKK3	Down	mRNA	Microarray	Mouse	Osteoblast cells	18505824
32	DLL1	Down	mRNA	Northern blot	Mouse	Neuroepithelial precursor (E10)	11466430
33	DUSP1	Up	mRNA	Gene chip array	Rat	Rat Wister bladder tumor cells (NBT-II)	18189245
34	DYNC2LI1	Up	mRNA	Gene chip array	Rat	Rat Wister bladder tumor cells (NBT-II)	18189245
35	EDNRA	Up	mRNA	Northern blot	Rat	Arterial smooth muscle cells	12851419
36	EFNB1	Up	mRNA	Gene chip array	Rat	Rat Wister bladder tumor cells (NBT-II)	18189245
37	ELF4	Up	mRNA	Gene chip array	Rat	Rat Wister bladder tumor cells (NBT-II)	18189245
38	FASN	Up	mRNA	RNA gel blot	Mouse	NIH 3T3 cells	7506544
39	FGF1	Up	mRNA	RT-PCR	Rat	Pheochromocytoma cells	8576258
40	FGF7	Up	mRNA	RT-PCR	Mouse	Embryonic lung mesenchymal cells	10446271
41	FN1	Up	mRNA	Gene chip array	Rat	Rat Wister bladder tumor cells (NBT-II)	18189245
42	FZD1	Down	mRNA	Microarray	Mouse	Osteoblast cells	18505824
43	FZD2	Down	mRNA	Microarray	Mouse	Osteoblast cells	18505824
44	FZD7	Down	mRNA	Microarray	Mouse	Osteoblast cells	18505824
45	FZD8	Down	mRNA	Microarray	Mouse	Osteoblast cells	18505824
46	F3	Down	mRNA	Northern blot	Human	Human umbilical vein endothelial cells	9157959
47	GADD45A	Down	mRNA	Microarray	Mouse	Osteoblast cells	18505824
48	HBEGF	Up	mRNA	Gene chip array	Rat	Rat Wister bladder tumor cells (NBT-II)	18189245
49	HMGA2	Down	mRNA	Northern blot	Rat	3T3-L1 cells	10490844
50	IBSP	Up	mRNA	in situ hybridization	Mouse	Mouse calvaria cells (coronal sutures)	12674336
51	IGF1	Down	mRNA	RT-PCR	Human	Fibroblasts	12008951
52	IGF2	Down	mRNA	RT-PCR	Human	Fibroblasts	12008951
53	IGF1R	Down	mRNA	RT-PCR	Human	Fibroblasts	12008951
54	IGF2R	Down	mRNA	RT-PCR	Human	Fibroblasts	12008951
55	IGFBP4	Down	mRNA	RT-PCR	Human	Fibroblasts	12008951
56	IL4	Up	mRNA	Q-PCR	Rat	Transected spinal cord tissue	21411654
57	IRS1	Down	mRNA	Microarray	Mouse	Osteoblast cells	18505824
58	LAMA3	Up	mRNA	Gene chip array	Rat	Rat Wister bladder tumor cells (NBT-II)	18189245
59	LRRC17	Down	mRNA	Microarray	Mouse	Osteoblast cells	18505824
60	MITF	Up	mRNA	Microarray	Mouse	Osteoblast cells	18505824
61	MMP13	Up	mRNA	Gene chip array, Q-PCR	Rat	Rat Wister bladder tumor cells (NBT-II)	18189245
62	MMP3	Up	mRNA	Northern blot	Rat	PC12 cell lines	11084019
63	MSH6	Up	mRNA	RNA gel blot	Mouse	NIH 3T3 cells	8870641
64	MSX2	Up	mRNA	in situ hybridization	Mouse	Mouse calvaria cells	12674336
65	NID2	Up	mRNA	Gene chip array	Rat	Rat Wister bladder tumor cells (NBT-II)	18189245
66	NOTCH1	Up	mRNA	Northern blot, Gene chip array, Q-PCR	Mouse, rat	Neuroepithelial precursor (E10), bladder tumor cells (NBT-II)	11466430, 18189245
67	NR1H3	Up	mRNA	RT-PCR	Rat	Astrocytes	19229075
68	ODC1	Up	mRNA	Northern blot	Mouse	NIH 3T3 cells	9223379
69	PDGFA	Up	mRNA	RNA gel blot	Human	HUVE cells	1689299
70	PFKL	Up	mRNA	RNA gel blot	Mouse	NIH 3T3 cells	7506544
71	PLAT	Up	mRNA	RT-PCR	Human	Fibroblasts	12008951
72	PLAUR	Up	mRNA	RT-PCR	Human	Fibroblasts	12008951
73	PLF	Up	mRNA	Northern blot	Mouse	NIH 3T3 cells	9223379
74	PMEPA1	Down	mRNA	Microarray	Mouse	Osteoblast cells	18505824
75	PNRC1	Up	mRNA	Gene chip array	Rat	Rat Wister bladder tumor cells (NBT-II)	18189245
76	POSTN	Up	mRNA	Northern blot	Rat	Pulmonary arterial smooth muscle cells	15121739
77	PPIA	Up	mRNA	Northern blot	Rat	PC12 cell lines	11084019
78	PRICKLE1	Down	mRNA	Microarray	Mouse	Osteoblast cells	18505824
79	PRPH	Up	mRNA	Northern blot	Rat	PC12 cell lines	11084019
80	PTPRE	Up	mRNA	Gene chip array	Rat	Rat Wister bladder tumor cells (NBT-II)	18189245
81	RUNX2	Up	mRNA	in situ hybridization	Mouse	Mouse calvaria cells (coronal sutures)	12674336
82	SCGB1A1	Up	mRNA	RT-PCR	Mouse	Mouse lung epithelium	12242715
83	SDC1	Up	mRNA	Gene chip array	Rat	Rat Wister bladder tumor cells (NBT-II)	18189245
84	SERPINB1	Down	mRNA	Microarray	Mouse	Osteoblast cells	18505824
85	SERPINB2	Up	mRNA	RT-PCR	Human	Fibroblasts	12008951
86	SERPINE1	Up	mRNA	RT-PCR	Human	Fibroblasts	12008951
87	SFRP1	Down	mRNA	Microarray	Mouse	Osteoblast cells	18505824
88	SFTPC	Up	mRNA	RT-PCR	Mouse	Mouse lung epithelium, Embryonic stem cell (mESC) line E14-Tg2a	12242715, 20497026
89	SOCS1	Up	mRNA	Northern blot	Rat	Mouse lens epithelium	14985304
90	SOCS3	Up	mRNA	Northern blot	Rat	Mouse lens epithelium	14985304
91	SOX2	Up	mRNA	Microarray	Mouse	Osteoblast cells	18505824
92	SPP1	Up	mRNA	Quantitative northern blot	Rat	Pulmonary arterial smooth muscle cells	15121739
93	SPRY1	Up	mRNA	RNA gel blot	Mouse	MC3T3-E1 osteoblasts	16604287
94	SPRY2	Up	mRNA	RNA gel blot	Mouse	MC3T3-E1 osteoblasts	16604287
95	SPRY4	Up	mRNA	RNA gel blot	Mouse	MC3T3-E1 osteoblasts	16604287
96	S1PR3	Up	mRNA	Northern blot	Human	Human umbilical vein endothelial cells	9315732
97	TCF3	Down	mRNA	Microarray	Mouse	Osteoblast cells	18505824
98	TCF4	Down	mRNA	RT-PCR	Human	Preadipocytes	22187378
99	TGFA	Up	mRNA	Northern blot	Mouse	Cultured keratinocytes	7535082
100	TGFB2	Down	mRNA	Microarray	Mouse	Osteoblast cells	18505824
101	TGFBR3	Down	mRNA	Microarray	Mouse	Osteoblast cells	18505824
102	THBS1	Down	mRNA	Microarray	Mouse	Osteoblast cells	18505824
103	THBS1	Up	mRNA	Northern blot	Mouse	NIH 3T3 cells	9223379
104	TIMP1	Up	mRNA	Gene chip array	Rat	Rat Wister bladder tumor cells (NBT-II)	18189245
105	TIMP3	Down	mRNA	Microarray	Mouse	Osteoblast cells	18505824
106	VIM	Up	mRNA	Gene chip array	Rat	Rat Wister bladder tumor cells (NBT-II)	18189245
107	ADIPOQ	Up	Protein	Radioimmunoassay	Human	Preadipocytes	17068114
108	CCNE1	Up	Protein	Western blot	Human	MG63 osteoblastic cells	15572039
109	CTNNB1	Down	Protein	Western blot	Human	Simpson Golabi Behmel syndrome (SGBS), Preadipocytes	22187378
110	HMOX1	Up	Protein	Western blot	Human	Spinal cord astrocytes	16524372
111	MMP7	Up	Protein	ELISA	Human	LNCaP cells	11922392	STAT3	6774	11922392
112	PKMYT1	Up	Protein	Immunoblot	Rat	Chondrosarcoma cells	21051949
113	PLIN1	Up	Protein	Western blot	Human, mouse	Preadipocytes, 3T3-L1 cells	17068114
114	PTGIS	Down	Protein	ELISA	Human	Endothelial cells	2107185
115	PTGS2	Down	Protein	ELISA	Human	Endothelial cells	2107185
116	RELA	Up	Protein	Western blot	Rat	ENU1564 cells	18041768
117	RHOA	Up	Protein	Immunoblot	Rat	Cardiomyocytes	19629561
118	SOX9	Up	Protein	Western blot	Mouse	Costal chondrocytes	10655493
119	WEE1	Up	Protein	Immunoblot	Rat	Chondrosarcoma cells	21051949
120	CDH2	Up	Protein	Western blot	Rat	PC12 cells	24396070	STAT3, SP1	6774, 6667	24396070
121	GAP43	Up	Protein	Western blot	Rat	PC12 cells	24396070	STAT3	6774	24396070