Journal of Signal Transduction

Signal Transduction Alterations in Glioma: Implications for Diagnosis and Therapy


Publishing date
08 Jun 2012
Status
Published
Submission deadline
09 Dec 2011

Lead Editor

1Istituto per l'Endocrinologia e l'Oncologia Sperimentale “G. Salvator” (IEOS), CNR, Naples, Italy

2Anatomia Patologica, Instituto Oftalmico, Hospital Universitario Gregorio Marañón, Madrid, Spain

3Cologne Center for Genomics, CECAD Cologne - Excellent in Aging Research, Cologne, Germany


Signal Transduction Alterations in Glioma: Implications for Diagnosis and Therapy

Description

Malignant gliomas are the leading cause of CNS tumour-related death, and patients with glioblastoma have a life expectancy of less than one year despite surgery, chemo-, and radio-therapy, and the prognosis is even worse in children with brain stem malignant gliomas.

Gliomas are divided into four clinical grades on the basis of their histology and prognosis. The most malignant grade 4 astrocytoma, or glioblastoma multiforme (GBM), either arises de novo (usually associated to EGFR pathway activation & PTEN inactivation leading to PI3K kinase/AKT activation pathway) or progresses from lower grade to higher grade over time (characteristically due to p53 and retinoblastoma pathways inactivation). Due to a combination of its complex phenotype and organ-specific clinical manifestations, efforts to refine GBM treatment with targeted therapies have largely been frustrated. Therefore, the identification and characterization of signal transduction pathways alterations, with a pathogenic role in glioma development and progression, may contribute to the identification of therapeutic targets aimed at a more efficient treatment.

Imaging based on magnetic resonance imaging and positron emission tomography plays an important role for primary diagnosis, planning of surgery and radiation, and in the determination of treatment response and time to tumor progression. Various molecular targets have been used to develop improved radiotracers, which may serve complementary information on the biology of gliomas.

We invite authors to contribute original research and review articles aimed to a better understanding of the signal pathways altered, leading to these diseases and to gain new insight into the development of signal pathways markers of innovative diagnostic, prognostic, and therapeutic modalities. Potential topics include, but are not limited to:

  • Understanding of aberrant signal transduction pathways in glioma
  • Epigenetic mechanisms producing signal pathways deregulation in gliomas
  • Angiogenic signalling pathways altered in gliomas: selection mechanisms for more aggressive neoplastic subpopulations with invasive phenotype
  • Understanding of glioma stem cells' biology
  • New Approaches in tumor imaging and biomarker development of pathways alterations, predictive of biological progression, and treatment response
  • Innovative strategies to treat glioma, applied to signal pathways alterations: antibodies, small molecules, siRNA, microRNA, nucleic acid aptamers, stem cells, viral, and nonviral gene therapy strategies

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/jst/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2012
  • - Article ID 704247
  • - Editorial

Signal Transduction Alterations in Glioma: Implications for Diagnosis and Therapy

Laura Cerchia | Juan-Carlos Martinez Montero | Parisa Monfared
  • Special Issue
  • - Volume 2012
  • - Article ID 597915
  • - Review Article

Angiogenic Signalling Pathways Altered in Gliomas: Selection Mechanisms for More Aggressive Neoplastic Subpopulations with Invasive Phenotype

Susana Bulnes | Harkaitz Bengoetxea | ... | José V. Lafuente
  • Special Issue
  • - Volume 2012
  • - Article ID 956958
  • - Review Article

DNA Methylation, Histone Modifications, and Signal Transduction Pathways: A Close Relationship in Malignant Gliomas Pathophysiology

Raúl Alelú-Paz | Nadia Ashour | ... | Santiago Ropero
  • Special Issue
  • - Volume 2012
  • - Article ID 483040
  • - Review Article

Antiangiogenic Therapy for Glioma

Valentina Cea | Carlo Sala | Chiara Verpelli
  • Special Issue
  • - Volume 2012
  • - Article ID 519807
  • - Review Article

Beyond Genetics in Glioma Pathways: The Ever-Increasing Crosstalk between Epigenomic and Genomic Events

Ramón Martínez
  • Special Issue
  • - Volume 2012
  • - Article ID 735135
  • - Review Article

Nucleic Acids in Human Glioma Treatment: Innovative Approaches and Recent Results

S. Catuogno | C. L. Esposito | ... | L. Cerchia
  • Special Issue
  • - Volume 2012
  • - Article ID 421564
  • - Review Article

Expression and Role of the Intermediate-Conductance Calcium-Activated Potassium Channel KCa3.1 in Glioblastoma

Luigi Catacuzzeno | Bernard Fioretti | Fabio Franciolini
  • Special Issue
  • - Volume 2012
  • - Article ID 282050
  • - Research Article

The Concept of Divergent Targeting through the Activation and Inhibition of Receptors as a Novel Chemotherapeutic Strategy: Signaling Responses to Strong DNA-Reactive Combinatorial Mimicries

Heather L. Watt | Zakaria Rachid | Bertrand J. Jean-Claude

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